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Enzymes that function primarily in the reductive direction utilize the NADP + /NADPH cofactor pair as cofactors as opposed to oxidative enzymes that utilize the NAD + /NADH cofactor pair

To obtain the semi-essential amino acid cysteine, cells assimilate its oxidized form, cystine, and then reduce its disulfide bond

Miyayama., et al., Mitochondrial electron transport is inhibited by disappearance of metallothionein in human bronchial epithelial cells following exposure to silver nitrate

Interestingly, in a pilot study, exposure of autologous glioma cells treated ex vivo with IGF-1R antisense oligos induced partial tumour regression in some patients with malignant astrocytoma (Andrews et al, 2001)