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269 The benefits of TZDs in MASLD and fibrosis may be the increased adiponectin levels and the adiponectin-mediated effect on insulin sensitivity and hepatic fatty acid metabolism 270 and the downregulated fibrogenic factors and related pathways, inflammatory pathways like JAK/STAT and NF-B signaling pathways

Given that the Wnt pathway shows many complex, negative and positive feedback loops interacting with redox systems and NK-B signaling, manipulations of Wnt signaling and -catenin (despite being a hub and master switch) appear to be very challenging

2003 Aug;26(8):1155-65