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The most commonly reported side effects (affecting more than 1 in 10 people) are gastrointestinal in nature and include: Nausea and vomiting Diarrhoea Abdominal pain Constipation These effects are typically most pronounced when starting treatment or increasing the dose, and often diminish over time as the body adjusts to the medication

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Guideline Recommendations Figure 3 includes the 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America HF guidelines and the 2023 European Society of Cardiology guidelines for the diagnosis and treatment of acute and chronic heart failure

J Biol Chem (1997) 272(52):328106