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This pathway might form an interface between the immune system and regulation of the pituitary-adrenal axis, particularly during chronic inflammation, where pro-inflammatory cytokines such as LIF might stimulate STAT3 expression and therefore POMC transcription (38)

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To illustrate animal behavior after retrobulbar application of the agents, each of the rats was mounted on an elevated surface (50 cm long, 20 cm width, and 30 cm high) and filmed for 1 min

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