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Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial

Anti-neoplastic action of cimetidine/vitamin C on histamine and the PI3K/AKT/mTOR pathway in Ehrlich breast cancer

I treat it as a tool with a strong mechanistic rationale, an excellent safety signal in the studies we have, and a body of evidence that's still maturing on the human side

Thus, the lofty vision of therapeutically lowering body weight in a manner that persists remains unmet