Seek urgent medical attention if you develop severe abdominal pain (which could indicate pancreatitis or gallbladder problems), persistent vomiting leading to dehydration, signs of allergic reaction, or a lump or swelling in the neck
That same clinical evidence base also shows that these medications don't work equally for every patient, that gastrointestinal side effects are common especially during dose escalation, and that weight tends to return when medication is discontinued without sustained lifestyle changes
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Chouik Y, Canivet CM, Julla JB, Mouillot T, Parlati L, Rouland A, et al