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Retatrutide also uniquely reduced epididymal adipose mass, a visceral fat depot, where the other interventions had no measurable effect.A separate line of research published in January 2025 in Advanced Science (Emory University / Winship Cancer Institute) examined retatrutide in the context of triple-negative breast cancer (TNBC) one of the most treatment-resistant breast cancer subtypes

Food and Drug Administration (FDA) approved Zepbound (tirzepatide) for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related condition, such as high blood pressure or type 2 diabetes

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Front Cell Dev Biol 9:711003