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There are other forms of bias in these datasets including channeling (e.g., the prescribing pattern depends on a patient characteristic (particularly diabetes or obesity) that is a PDAC risk factor), detection (e.g., overreporting due to additional testing to rule out a suspected adverse event (e.g., imaging triggered by pancreas enzyme elevations)), and Weber effect (initial increase in event reporting shortly after drug launch) 49

Neurotherapeutics 18 , 309325 (2021)

Comprender estos aspectos tcnicos mejora la adherencia al tratamiento y los resultados teraputicos

Pfizer decided to scrap its trial of danuglipron, an experimental oral GLP-1 agonist, after the once-daily drug caused liver injury in a phase 3 trial participant