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Researchers at the University of Virginia, supported by National Institutes of Health funding, found that oral small-molecule GLP-1 receptor agonists, including orforglipron, penetrate deeper into the brain than previously understood

Some of the most common side effects are: Nausea Constipation Headache Vomiting Dizziness Insomnia Dry mouth Diarrhea Additional side effects include: Anxiety Hot Flush Fatigue Tremor Upper abdomen pain Viral gastroenteritis Influenza (Flu) Tinnitus (Ringing in the ears) Urinary tract infection Excessive sweating Irritability Increased blood pressure Changes in taste and smell Rashes Muscle strains Palpitations

Curr Cardiol Rev 9 , 3354 (2013)