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Proteases in the peritoneal fluid appear to degrade GLP-1 faster than normal, creating a pro-inflammatory environment where the natural braking mechanisms on inflammation are weakened

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For eligible adults with clinically significant obesity, MHRA-approved options include semaglutide (Wegovy, assessed in NICE TA875) and tirzepatide (Mounjaro, assessed in NICE TA1026), both available through NHS pathways with appropriate clinical oversight