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Results FXR regulates GLP-1 secretion in response to SCFAs in the murine colon To assess whether FXR plays a role in the colonic L-cell response to SCFAs, an ex vivo GLP-1 secretion test in response to butyrate was performed on murine colon biopsies from WT mice treated orally for 5 days with vehicle or the synthetic FXR agonist GW4064 (30 mg/kg)

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