Functionally, melatonin can link changes in external light signals and multiple physiological activity rhythms ( Melatonin was originally isolated and identified from the pineal glands of animals ( Additionally, many studies have demonstrated that some bacteria and fungi can synthesize melatonin ( Eryrobacter longusits , demonstrating that it could synthesize and secrete melatonin under weak light conditions
Therefore, we speculate that GLP-1RA transdermal administration may suppress energy intake and nutrient absorption, ultimately leading to greater weight loss in the TDDS group
R.CozzolinoF.RotilioG.et al (2003)
Da Silva T, Hafizi S, Andreazza AC, Kiang M, Bagby RM, Navas E, Laksono I, Truong P, Gerritsen C, Prce I, Sailasuta N, Mizrahi R