However, the weight loss results have not been staggering, with most patients experiencing between two to three percent body weight loss while taking berberine
They simultaneously target GIP and glucagon receptors, meaning we will need to be hyper-vigilant about a completely new metabolic profile, including heart rate variations and heightened gastrointestinal or energetic shifts. A physiatry and family medicine resident on Sermo flagged a risk that comes with rapid weight loss, My biggest clinical concern with such rapid and massive weight reduction is how we will effectively monitor and preserve lean muscle mass to prevent medically induced sarcopenia, especially as these indications expand to older populations. That worry about preserving lean muscle is already familiar to many physicians from the current GLP-1 class
Adhering to medication schedules: Following the prescribed dosage and timing to ensure efficacy
Eur J Heart Fail 25(11):19361943 Salvatore T, Galiero R, Caturano A, Vetrano E, Rinaldi L, Coviello F, Di Martino A, Albanese G, Colantuoni S, Medicamento G et al (2022) Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes
