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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly

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Guided by previous studies 19,20 , uridine was added to the culture medium at concentrations of 10, 50, 100, and 200 M to evaluate PB1 extrusion in oocytes (Supplementary Fig

We therefore grouped overlapping metabolites into biochemically coherent modules across all three outcomes: one-carbon metabolism ( Figure 5A ), alternative carbon sources ( Figure 5B ), and tryptophan degradation ( Figure 5C )