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GLP-1 medications are typically considered for adults who: Have a Body Mass Index (BMI) of 30 or higher Have a BMI of 27 or higher with weight-related conditions such as diabetes or hypertension Have not achieved sustained weight loss through lifestyle modification alone These medications are intended for long-term weight management, not short-term or cosmetic weight loss

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Yang F, Leung VY, Luk KD, Chan D, Cheung KM: Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse

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