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These compounds have been shown to increase melanin content in B16F10 cells and in a three-dimensional skin model by increasing the expression of melanin-related proteins such as MITF, TYR, and TRP-1 [258,259,260]

While supraphysiological cortisol levels alone can induce IUGR, as discussed in Section 4, increased fetal cortisol bioavailability is considered a consequence rather than a cause in the most common type of IUGR, which is characterized by late-onset placental insufficiency with brain-sparing effects (267, 268)

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Many dietary supplements provide iodine as potassium iodide or from algae sources (mainly kelp), with a titrated dose within the range of 150225 g/day