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Several important safety considerations from UK SmPCs include: Pancreatitis risk : Seek immediate medical attention for severe, persistent abdominal pain Gallbladder disease : Including cholelithiasis and cholecystitis Diabetic retinopathy complications : Particularly with semaglutide in those with pre-existing retinopathy Dehydration and acute kidney injury : Possible with severe gastrointestinal side effects Hypoglycaemia : Increased risk when used with insulin or sulfonylureas (dose adjustment of these medications may be needed) Pregnancy/breastfeeding : Weight management GLP-1 agonists (Wegovy, Saxenda) are contraindicated in pregnancy and should be avoided during breastfeeding [5] [2] Regarding mental health specifically, regulatory agencies have scrutinised GLP-1 medications for potential psychiatric adverse effects

We've heard stories of entire batches of research material being ruined by a forgotten vial left on a lab bench

Nadia Ahmad, the medical director for Eli Lilly and Companys obesity product development, says this long string of safety issues and product failures is why the field has been considered such a gamble for pharma companies

It unleashed this whole parallel industry, a separate pipeline outside of the control of big pharma