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Dosing of tramadol in older patients should reflect their physiological changes, it is recommended that the dose of tramadol is started low (50mg) and titrated upwards until an analgesic level is found that does not cause adverse effects, the option of increasing the dosage interval could also be considered

is supported by the Miguel Servet program run by the Fondo de Investigacin Sanitaria (ISCIII) (grant number CP13/00098)

Based on these data, we proposed that the inflammatory response, associated with the disease, can be efficiently treated by the topical administration of zileuton, the only specific inhibitor of 5-LOX, approved by the US FDA [36,55]

GLP-1-directed NMDA receptor antagonism for obesity treatment