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Journal of Bioinformatics and Computational Biology 14 , 1650005 (2016)

In the absence of MTAP, the substrate methyl thionyl adenosine (MTA) accumulates and acts as a selective inhibitor of PRMT5 to inhibit PRMT5 methylation activity, 237 whereas MAT2A can produce the PRMT5 substrate SAM, 238 allowing PRMT5 to exert its oncogenic effect

Discuss with your GP whether continuing Ozempic aligns with your long-term management plan for PCOS, alongside other interventions such as metformin for metabolic features (though this is an off-label use in PCOS in the UK)