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GIP receptor (GIPR) activation Enhances glucose-dependent insulin secretion via cAMP/PKA pathways Stimulates -cell proliferation and reduces apoptosis Contributes to appetite suppression without significant nausea 2

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We understand that the determination of potential 340B-eligibility of a PDE record using the methodology described herein does not necessarily mean that the covered entity replenished (or can in the future replenish) the units at the 340B price, and we therefore believe the proposed claims-based methodology may overestimate the number of units that are units for which a manufacturer provided a discount under the 340B Program