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The Warburg effect results in a dramatic increase in intracellular levels of acetyl coenzyme A (Ac-CoA), which induces general control non-derepressible 5 protein/Spt-Ada Gcn5-acetyltransferase (Gcn5p/SAGA)-catalyzed acetylation of histone proteins, which induces downstream gene transcription and promotes cell growth
Statements Acknowledgments This work was supported by grants from Federico II University of Naples (Italy)
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