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doi: 10.1007/s40261-021-01038-1 Pubmed Abstract CrossRef Google Scholar View reference in article 10 SuwannasomNKaoIPruAGeorgievaRBumlerH

Exendin-4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor-kappa B and osteoprotegerin signaling pathway

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So, while there are recommended limitations to its use, aspartame consumption according to the FDA is likely safe for those consuming far less than the established ADI