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We then performed ChIP analysis and confirmed the recruitment of TR to the super-enhancer region containing two putative TR binding sites (Fig

Improvement in fibrosis was also assessed, showing a dose-dependent trend, with 34% of patients achieving at least a 1-stage improvement in fibrosis without MASH progression in the 6 mg group (vs

Considering the widespread expression of GLP-1 receptors in the brain, the authors recommend that future studies should focus on identifying the key neurocircuits involved in mediating the effects of GLP-1 receptor agonists on substance use disorder, as well as determine the specific patient subtypes who are most likely to benefit from these treatments