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Whether pituitary hormones are also important for the cardioprotective effects of central leptin-melanocortin activation remains uncertain and awaits further investigation

In other words, carnitine may have a slight beneficial effect on fat metabolism even without exercise, but this effect is often insufficient to result in significant weight loss or other notable improvements in body composition

*Correspondence: Alejandro Gonzlez-Candia [email protected] This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Cardiovascular safety for once-weekly dulaglutide in type 2 diabetes: a pre-specified meta-analysis of prospectively adjudicated cardiovascular events