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10.1016/j.expneurol.2020.113538 Exp Neurol

RT protocol During the study period, all subjects participated in the RT program, which was held in a commercial gym, twice a week

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LIP-derived Fe 2+ participates in Fenton reactions, generating hydroxyl radical species that drive membrane lipid peroxidation and subsequent ferroptosis (Morales and Xue, 2021), furthermore, ferritin-bound iron undergoes Nuclear receptor coactivator 4 (NCOA4)-mediated autophagic degradation in lysosomes, releasing free Fe 2+ into the intracellular compartment ( The Fenton reaction, mediated by Fe 2+ and hydrogen peroxide, generates hydroxyl radicals that initiate non-enzymatic lipid peroxidation by abstracting hydrogen atoms from lipids, forming lipid radicals (Sun et al., 2022)