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Developed countries have experienced a steady increase in disorders of immune dysregulation since the 1980s, including type 1 diabetes mellitus, inflammatory bowel diseases, rheumatoid arthritis, multiple sclerosis, and asthma (174, 175)

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Summary of laboratory model and mechanistic signaling observations Data from documented laboratory peptide signaling studies Documented interactions in GH secretagogue research models Peak elevation in research models Teichman et al., 2006 Reduced time to peak GH pulse Bowers et al., 1991 Physiologic rhythm maintenance Teichman et al., 2006 Verified in laboratory settings Raun et al., 1998 GH secretagogue research suggests pathway activity that supports protein synthesis and lipid oxidation modeling