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Curcumin can also markedly upregulate CD3 - CD19 + CD1d + , CD3 - CD19 + CD25 + , CD3 - CD19 + Foxp3 + Breg cells level and significantly down-regulate CD3 - CD19 + PD-L1 + , CD3 - CD19 + tim-1 + , CD3 - CD19 + CD27 + Breg cells level in DSS-induced colitis mice [264]

In the first step, the enzyme fragments which can bind with the substrate were screened to find the binding peptides

mTOR activity was assessed by western blot and flow cytometry

Previous studies have attempted to investigate the potential mechanisms explaining the differences observed in the efficacy of DPP-IV inhibitors between Asians and non-Asians