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In addition, artemisinin increases ROS levels, and FIN56 binds and activates squalene synthase to accumulate ROS (Kang et al., 2019), leading to the depletion of endogenous antioxidant CoQ10 and then inducing ferroptosis by lipid peroxidation

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Both genetic and environmental models demonstrate reduced taste receptor expression, especially in the hypothalamus and brainstem, but no significant changes in cortical or hippocampal expression (123)