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Animal studies suggest that it doesnt raise levels of cortisol or prolactintwo other hormones that can have a negative impact on body composition

Pathway / Mechanistic Context Ipamorelin is used to probe GHSR-1a-linked GPCR signaling in which receptor engagement can trigger calcium mobilization and modulation of adenylate cyclase activity, leading to downstream phosphorylation events and transcriptional responses

[4] An increase in cAMP levels may activate protein kinase A (PKA), which might, in turn, phosphorylate several proteins, such as the voltage-dependent calcium channels in the cell membrane

And they are working to remove the black box warning on hormones