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146 MARCHF6, known as TEB4 or RNF176, is a large ER-resident ERAD E3 ubiquitin ligase with multiple transmembrane domains and comprises an N-terminal RING domain and C-terminal sequences that function in self-regulation

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Therefore, the tissue-specific effects of l-carnitine are likely to be different among species, and thus more low-carnitine animal models should be established to intensively evaluate the possible different functions of l-carnitine among species