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Furthermore, we demonstrate that GLP-1R C347K and C347R mutant proteins can be activated by a non-specific five residue linker in the complete absence of GLP-1 or EX4 sequences, yet this activation remains completely dependent on the ECD, suggesting that the ECD plays a much more dominant and direct role in the receptor activation

61.58% of consumers say GLP-1 friendly foods are more expensive, indicating that brands must balance premium ingredients with accessible price points

stopping their use without sustained lifestyle changes may lead to regained weight

The researchers also did not directly account for treatment duration or adherence, both of which are known to influence long-term outcomes