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A large, randomised, placebo-controlled trial assessing OIPN using CTCAE grades and patient-reported outcomes is warranted to confirm these findings

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Mice subjected to 6 weeks of prolonged stress followed by 6 weeks of social isolation exhibit symptoms of depression, accompanied by elevated levels of astrocyte activation in the dorsal and ventral dentate gyrus regions of the hippocampus (Woodward et al., 2018)