Tirzepatide continues to be the most prescribed anti-diabetic (ADM) and anti-obesity (AOM) medication (sold as Mounjaro and Zepbound, respectively) and showed the largest increase in total prescribing from September to December 2025
Consider seeking advice if you experience irregular or absent periods, unexplained weight gain that does not respond to lifestyle changes, symptoms of excess androgens such as hirsutism or persistent acne, or if you are struggling with fertility concerns
Fatouros IG, Douroudos I, Panagoutsos S et al Effects of L-carnitine on oxidative stress responses in patients with renal disease
The evidence base includes STEP (semaglutide for weight management, The New England Journal of Medicine , 2021), SURMOUNT (tirzepatide for weight management, NEJM 2022), and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024)