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Average weight loss is 15% of body weight in 12 months

Zepbound (tirzepatide) carries the same chronic weight management indication and an additional indication for moderate-to-severe obstructive sleep apnea in adults with obesity

Pharmacological interventions are more limited, with antidepressants such as duloxetine (a serotonin-noradrenaline reuptake inhibitor) or amitriptyline (a tricyclic antidepressant) sometimes considered

Besides well-known oxidants or electrophiles, such as H 2 O 2 , 4-hydroxynonenal, and diethyl maleate (DEM), which also possess cytotoxicity, only few Nrf2 activators have been found to be useful in clinical trials (Sun et al