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Mitochondrial dysfunction further exacerbates oxidative stress by impairing ATP production and damaging mitochondrial DNA, leading to compromised sperm motility and energy deficits

In the pivotal STEP 1 clinical trial, participants who received weekly semaglutide injections lost an average of 14.9% of their body weight over 68 weeks , compared with 2.4% in the placebo group (study in the New England Journal of Medicine )

Massive ingestion : Defined as patients with any of the following: Serum acetaminophen level The serum acetaminophen concentration is the basis for diagnosing acute acetaminophen poisoning and determining the need for treatment