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Common Side Effects of Mounjaro, Wegovy, Ozempic, and Rybelsus The most common side effects are gastrointestinal and may include: Nausea Vomiting Diarrhea Constipation Bloating Abdominal discomfort Most side effects improve as the body adjusts to treatment

But everyone's tolerance is different, as is what triggers gastrointestinal discomfort, so it may take a little trial and error

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At higher doses used specifically for weight management (Wegovy 2.4mg or experimental high-dose oral semaglutide), people typically lose about 15% of their body weight over 68 weeks