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The GLP-1 receptor arm drives glucose-dependent insulin secretion alongside suppression of pancreatic alpha-cell glucagon output, slows gastric emptying, and engages central nervous system appetite-modulating circuits in the hypothalamus and brainstem (PMID 39515565)

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Kaiser Permanente is an integrated health system where doctors and insurance are part of the same organization

These combined properties make papaya a promising candidate for mitigating neurodegenerative processes, including those associated with diabetic encephalopathy 22,23