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By supporting adrenal function with targeted adaptogens, Calm helps to modulate the stress response, which, in turn, modulates the histamine response

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"The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice and 3-AR Knock-Out Mice." Endocrinology 142.12 (2001): 5182-5189