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It is currently unclear whether GLP1RAs resistant to degradation produce the same effects on blood flow as native GLP1

When to speak to your GP Contact your GP or prescriber if you experience any of the following while taking Wegovy: New or worsening anxiety symptoms that interfere with daily life Persistent low mood or feelings of hopelessness Thoughts of self-harm or suicide Severe nausea or vomiting that prevents you from taking your anxiety medication Panic attacks that are new or more frequent Significant changes in sleep patterns Difficulty eating enough due to reduced appetite, particularly if its affecting your energy and mood Your prescriber can adjust doses, stagger medications, or explore alternative treatments if needed

Berberine moderate inhibition of CYP3A4 is therefore significant