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They are also potent antioxidants that can protect the cells from oxidative damage and lower the risk of cancer, by inducing apoptosis, inhibiting angiogenesis, and modulating the immune system

An adjustment to dosage or a change in medication may be warranted

The mechanisms of action involve modulation of sleep-regulating neurotransmitters and neuroendocrine systems including enhancement of delta wave activity during deep sleep stages, regulation of cortisol and stress hormone rhythms that impact sleep quality, optimization of circadian rhythm signaling for proper sleep-wake cycles, support for melatonin and sleep-promoting pathways, and modulation of pain perception which can interfere with sleep quality

29 A statistical analysis of 17 randomized controlled trials that included a total of over 1,000 participants found that intake of probiotics, prebiotics (partially or completely indigestible carbohydrates that enhance growth of beneficial gut bacteria), or synbiotics (combinations of probiotics and prebiotics) was of benefit for metabolic aspects of PCOS