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Abstract Diabetes is one of the main risk factors for the development of cognitive dysfunction

Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss

Research has shown that UA can facilitate the formation of mitochondrial respiratory chain complexes and enhance their function, increasing ATP synthesis in muscle cells (6)

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