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This process is known as adaptive homeostasis or allostasis (Sies et al., 2022)

Use in Paediatrics: NASO B12 NASAL SPRAY is advised to be used with caution in children and adolescents (aged below 18 years)

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Shared epigenetic mechanisms in depression-drug addiction comorbidity To better integrate these findings, we introduce a unifying three-axis framework, stress-response regulation, reward-circuit remodeling, and synaptic plasticity, which provides a coherent structure for understanding how epigenetic alterations converge across depression, drug addiction, and drug addiction-induced depression