This process can make a drug more active, less active, or even inactive
The level and significance of circulating Angiotensin-III in patients with coronary atherosclerosis
doi: 10.1186/1477-7827-10-82 126 KrawetzSAKrugerALalancetteCTagettRAntonEDraghiciSet al
2 L-serine and metabolic regulation 2.1 L-serine forms a complex metabolic network As a glycogenic amino acid, L-serine has various sources, such as an external diet, intracellular synthesis (from the glycolytic intermediate 3-phosphoglycerate and glycine), and cleavage of proteins and phospholipids in vivo ( in situ ( de novo synthesis, L-serine is converted from 3-phosphoglycerate (3-PG), an intermediate of glycolysis, through a three-step enzymatic reaction, in which 3-phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme ( Figure 1a ) ( Figure 1b ) ( Figure 1 Therefore, L-serine is a precursor molecule for the synthesis of many substances, and the metabolism of L-serine includes the synthesis of amino acids, phospholipids, and proteins ( Figure 1c ) ( Figure 1d ) ( Figure 1