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129 Paroxetine has also been shown to inhibit the inflammatory response in UC by blocking the interaction between G protein-coupled receptor kinase 2 (GRK2) and prostaglandin E2 receptor 4 (EP4), thereby reducing cyclic adenosine monophosphate (cAMP) levels and regulating M2 macrophage polarization

2.2 Esophageal microbiome in reflux The microbiome changed with the spatial structure of the esophagus

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