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Every single one of the genetic combinations she lists below should be able to tolerate B12 in the form of Hydroxy B12 (and this is why our methylation protocol suggests Hydroxy B12 as the B12 form to begin with): Folks with multiple COMT mutations tend to do very well with Hydroxy B12 (it helps mop up excess peroxynitrites which can cause problems) Folks with MTR & MTRR mutations may do well with methylcobalamin & adenosylcobalamin supplementation And Dr

Signs in infants and young children (often appearing around 4-6 months): Irritability and sleep disturbances Developmental delays or regression Poor muscle tone and coordination problems Speech difficulties White matter abnormalities on brain imaging In adults: Movement disorders Balance and coordination problems Cognitive decline and memory loss Mood changes The symptoms can range from mild behavioral changes to severe, progressive neurological deterioration

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However, a randomized casecontrol study revealed that wakame (Undaria pinnatifida) intake (5 g/day) in brown algae significantly decreased blood pressure in 36 older Japanese individuals with hypertension (41)