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While high sheer stress caused by vasoconstriction is considered atheroprotective during the early phases of atherogenesis, it later predisposes individuals to more vulnerable plaque phenotypes that cause MI and stroke 42

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The lack of standardized methods to evaluate total antioxidant capacity and the oxidation state and the use of inadequate antioxidants and/or improper concentrations of antioxidants lead to failure of numerous clinical trials directed to prevent or mitigate progression of atherosclerosis (230233)

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