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Specifically, mycotoxins have been shown to: Suppress cytokine production, altering immune signaling Induce apoptosis (programmed cell death) in immune cells Disrupt the intestinal epithelial barrier, contributing to leaky gut Impair macrophage and dendritic cell function Alter the balance between inflammatory and regulatory immune pathways (Th1/Th2/Th17/Treg axis) Aspergillus fumigatus produces gliotoxin, which actively suppresses the immune systems ability to fight off fungal infection by inhibiting phagocytosis

Woulds were induced on each rabbit and the rabbits were presented with the respective compounds for 21 consecutive days

Given the detrimental impact of mHE, there is an urgent need to translate diagnostic criteria and tests into pragmatic everyday clinical practice [24]