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33 In a study of GSH systemic availability by Witschi et al showed that it is impossible to boost serum GSH level to a clinically benecial level even after oral administration of a high single dose of 3 g

This study was reported in accordance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) statement guidelines for cohort studies [27] which is listed in the supplementary information

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Despite being a predominantly nuclear protein, several studies have indicated that during elevated ROS that ATM may translocate through the nuclear membrane to interact with cytosolic proteins localised in the peroxisome, mitochondria and microsome 52,53,54