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Studies reporting adjusted analyses had low to moderate risk of bias, whereas those reporting only crude estimates had a serious risk of bias, mainly due to confounding

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As such, a recent study highlighted the importance of TNF- inhibitors in AS therapy, showing that TNF- inhibitors were superior to IL-6, -17, -23, and JAK inhibitors regarding efficacy and safety and should be used as the preferred replacement for conventional drug therapy in patients suffering from a rapid disease progression and physical functional limitations [73]

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