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GLP-1 and GLP-2 orchestrate intestine integrity, gut microbiota, and immune system crosstalk

These findings emphasize the need for a personalized approach in clinical decision-making, balancing efficacy goals with tolerability to optimize adherence and long-term outcomes

de novo lipogenesis, along with downregulating enzymes linked to lipid synthesis, such as ACC and FAS (Lyons and Beaudry, 2023)

Another meta-analysis (50 randomized controlled trials) performed to assess the association between DPP-4is and the risk of HF in T2D patients evidenced that vildagliptin appears to be the safest option with regard to the risk of HF, followed by saxagliptin, sitagliptin, linagliptin, and alogliptin [153]